By Errol C Friedberg
With a Foreword via Sydney Brenner (Nobel laureate in body structure or medication, 2002)
This biography information the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's lifestyles from delivery, in 1926, to the current, with exact emphasis on his huge, immense clinical contributions, together with being the 1st to advance know-how that ended in gene cloning technology. In 1980, Berg obtained a Nobel Prize in chemistry for this work.
In addition to his contributions within the learn laboratory, Berg orchestrated and oversaw a ancient assembly at Asilomar, California that headquartered on a threatening controversy surrounding the belief by way of a number of the destructive strength of recombinant DNA expertise. This assembly did a lot to prevent this controversy and to install position the rules of recombinant DNA paintings, hence placing fears to rest.
The recombinant DNA controversy was once a old end result of the invention of gene cloning. particularly, it represented a paramount instance of clinical foresight and due diligence by way of the medical neighborhood, instead of via regulatory entities within the usa and lots of different international locations. the final word popularity of gene/DNA cloning resulted in a brand new period of contemporary biology that flourishes to the present.
This e-book is aimed basically at scientists and people in education. The booklet strives to easily supply info for the overall reader, yet isn't really particularly adapted for a common interpreting audience.
While many books disguise the recombinant DNA controversy, none have satisfactorily addressed this historical interval and are usually contradictory concerning the many who is, where's, and why's concerned. also, the good majority of those have been written by way of non-scientists. This biography of Paul Berg presents entry to various archived letters and files at Stanford college no longer formerly addressed, and to the chronology of occasions as recalled and documented via him, in addition to different key personalities, lots of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and global struggle II
- Western Reserve University
- Part II:
- Washington collage, St. Louis
- Discovering move RNA
- Stanford college — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — a massive Breakthrough
- EcoRI limit Endonuclease — an incredible Breakthrough
- “Coincidence is the observe We Use once we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An historical assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon learn Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a unique aspect of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage matters — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in existence sciences, medication and chemistry and lay public.
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